Depth Chart
| Offense | |||
| Position | |||
| Left Tackle | Trent Williams | Colton McKivitz | |
| Left Guard | Aaron Banks | Daniel Brunskill | |
| Center | Jake Brendel | ||
| Right Guard | Spencer Burford | Nick Zakelj | |
| Right Tackle | Mike McGlinchey | Jaylon Moore | |
| Wide Receiver | Brandon Aiyuk | Danny Gray | Jauan Jennings |
| Wide Receiver | Deebo Samuel | Ray-Ray McCloud III | |
| Running Back | Christian McCaffrey | Elijah Mitchell | Jordan Mason |
| Tight End | George Kittle | Ross Dwelley | Charlie Woerner |
| Quarterback | Brock Purdy | Josh Johnson | Jimmy Garoppolo |
| Defense | |||
| Position | |||
| Left Defensive End | Samson Ebukam | Charles Omenihu | Kerry Hyder Jr. |
| Left Defensive Tackle | Javon Kinlaw | Kevin Givens | |
| Right Defensive Tackle | Arik Armstead | T.Y. McGill | |
| Right Defensive End | Nick Bosa | Jordan Willis | Drake Jackson |
| Strong Linebacker | Azeez Al-Shaair | Oren Burks | |
| Middle Linebacker | Fred Warner | ||
| Weak Linebacker | Dre Greenlaw | Demetrius Flannigan-Fowles | |
| Left Cornerback | Deommodore Lenoir | Jimmie Ward | Ambry Thomas |
| Right Cornerback | Charvarius Ward | Samuel Womack III | |
| Strong Safety | Talanoa Hufanga | Tarvarius Moore | |
| Free Safety | Tashaun Gipson Sr. | George Odum | |
| Special Teams | |||
| Position | |||
| Kicker | Robbie Gould | ||
| Kick-Offs | Robbie Gould | ||
| Punter | Mitch Wishnowsky | ||
| Kick Returner | Ray-Ray McCloud III | Danny Gray | |
| Punt Returner | Ray-Ray McCloud III | Brandon Aiyuk | |
| Holder | Mitch Wishnowsky | ||
© 2023 by STATS PERFORM.Any commercial use or distribution without the express written consent of STATS PERFORM is strictly prohibited.
